The crisis in clinical care imposed by the increasing resistance of bacterial infections to antibiotics threatens to return clinical practice to the pre-antibiotic era ( Boucher et al., 2009 Centers for Disease Control, 2013 Bassetti et al., 2017 World Health Organization, 2017). The phages presented here are currently being characterized in animal models and are available for eINDs. Clinical scenarios in which these phages can potentially be used are discussed. This information is required before phages can be added to a phage library for potential human use or sharing between laboratories for use in compassionate use protocols in humans under eIND (emergency investigational new drug). The basic phage characteristics on the isolation host, sequence analysis, growth properties, and host range and virulence on a number of contemporary clinical isolates are presented. Here we describe the generation of phage libraries for three target species: Escherichia coli, Pseudomonas aeruginosa, and Enterobacter cloacae. Phage therapy requires libraries of well-characterized phages. 4Department of Medicine, Baylor College of Medicine, Houston, TX, United States.DeBakey VA Medical Center, Houston, TX, United States 3Center for Innovations in Quality, Effectiveness and Safety, Michael E.
2Department of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.1Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
0 kommentar(er)
